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Aprotinin and Long Term Mortality

 

 

APPENDIX 1A   |  APPENDIX 1B   |  APPENDIX 2A   |  APPENDIX 2B   |  APPENDIX 3   | 

 APPENDIX 4   |  APPENDIX 5   |  APPENDIX 6   |  APPENDIX 7   |  APPENDIX 8

APPENDIX 1

Univariates

  APPENDIX 1A:  Primary Univariates (see Reference 1)

  The following are the 97 variates selected prospectively for multivariable analysis.

Univariate Factors

 

  Cardiovascular Variables

Gastrointestinal Variables

  History of hypertension

History of gastrointestinal disease

  History of antihypertensive Rx

History of liver disease

  History of smoking: regularly smoked

History of alcohol abuse

  History of smoking: current

 

  History of diabetes

Other Organ Variables

  History of diabetes (NIDDM)

History of hematologic disorder

  History of diabetes (IDDM)

History of anemia

  History of hypercholesterolemia

Admission: hemoglobin < 10 gm

  History of angina

History of IV drug use

  History of unstable angina

History of pulmonary disease

  Preop: angina/ischemia

History of peripheral vascular disease

  Preop: Left main coronary disease

 

    (cardiac catheterization)

Surgical & Demographic Variables

  History of myocardial infarction

Surgery: emergency

  History of myocardial infarction within 90 days  

Surgery: urgent

    (prior to surgery)

Surgery: CABG only

  History of number of myocardial infarctions > 1

Surgery: CABG + valve (without other

  Preop: myocardial infarction

  cardiac/noncardiac surgery)

  History of CHF

Surgery: other combined surgery

  History of CHF with hospitalization

Surgery: ≥  3 grafts

  Admission: CHF

Demo: gender

  Preop: CHF

Demo: BSA

  Preop: cardiomegaly (CXR)

Demo: ethnicity-African-American or Hispanic or

  Preop: left ventricular aneurysm

  Am. Indian

    (cardiac catheterization)

Demo: ethnicity-Asian

  Preop: EF (minimum) (cardiac catheterization)

Demo: ethnicity-Caucasian

  Preop: EF (normal-mild vs moderate severe)

Demo: ethnicity-Hispanic

    (cardiac catheterization)

Demo: age

  Preop: IABP

Demo: private insurance

  History of dysrhythmia

 

  History of tachyarrhythmias

Medication Variables

  History of conduction abnormality

Preop: Medications-ACE inhibitors

  History of heart block

Intraop: Medications-ACE inhibitors

  History of unknown dysrhythmia

Preop: Medications-antiarrhythmics

  History of valve disease

Inraop: Medications-antiarrhythmics

  History of PTCA

Preop: Medications-anticoagulants

  History of coronary endarterectomy

Intraop: Medications-anticoagulants

  History of coronary atherectomy

Preop: Medications-beta blockers

  History of intracoronary stent

Intraop: Medications-beta blockers

  History of CABG

Preop: Medications-bronchodilators

  History of valve surgery

Intraop: Medications-bronchodilators

  History of other cardiac surgery

Preop: Medications-calcium channel blockers

  History of other noncardiac surgery

Intraop: Medications-calcium channel blockers

 

Admission: Warfarin/coumadin (past week)

  Cerebrovascular Variables

Preop: Medications-diuretics

  History of carotid disease

Intraop: Medications-diuretics

  History of transient ischemic attack

Preop: Medications-inotropes

  History of syncope

Intraop: Medications-inotropes

  History of seizures

Preop: Medications-nitrates

  History of stroke

Preop: Medications-K+ channel blockers

  History of head trauma

Preop: Medications-platelet inhibitors

  History of carotid endarterectomy

Preop: Medications-peripheral vasodilators

  Admission: stroke

Intraop: Medications-transfusion: FFP

 

Intraop: Medications-transfusion: RBC 

  Renal Variables

Intraop: Medications-transfusion-platelets

  History of renal disease

Intraop: Medications-antibiotics

  Preop: creatinine

 

 

 

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