IREF is dedicated to discovering and communicating significant insights into cardiovascular disease, cancer, drug safety, and health that have the potential to:

• reduce healthcare costs
  
• increase access and equity
  
• challenge the status quo
  
• break the mold and reset protocols
  
• identify effective generic therapies
  
• support health promotion, and
  
• improve the quality of life worldwide.

We achieve our mission by conducting high quality clinical research and publishing the results for the public benefit. IREF is an independent, nonprofit, California-based foundation, dedicated to performing quality medical and scientific research with its close affiliate, the Multicenter Study of Perioperative Ischemia (McSPI) Research Group, and other worldwide collaborators, for the purpose of saving and extending lives and promoting responsible healthcare practices.